Tankersley , Philip L . Smith , Alan R . Schwartz and Christopher P . O ' Donnell Vsevolod Y . Polotsky , Marc C . Smaldone
نویسندگان
چکیده
physiology, especially those papers emphasizing adaptive and integrative mechanisms. It is published 12 times a publishes original papers that deal with diverse area of research in applied
منابع مشابه
HIGHLIGHTED TOPIC Upper Airway Control and Function: Implications for Sleep-Disordered Breathing Leptin and the control of pharyngeal patency during sleep in severe obesity
Steven D. Shapiro, Chien-Hung Chin, Jason P. Kirkness, Brian M. McGinley, Susheel P. Patil, Vsevolod Y. Polotsky, Paolo Jose Cesare Biselli, Philip L. Smith, Hartmut Schneider, and Alan R. Schwartz Johns Hopkins Sleep Disorders Center, Division of Pulmonary & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland; Division of Pulmonary and Critical Care Medicine, Departme...
متن کاملImpact of interrupted leptin pathways on ventilatory control.
Leptin deficiency in ob/ob mice produces marked depression of the hypercapnic ventilatory response, particularly during sleep. We now extend our previous findings to determine whether 1) leptin deficiency affects the hypoxic ventilatory response and 2) blockade of the downstream excitatory actions of leptin on melanocortin 4 receptors or inhibitory actions on neuropeptide Y (NPY) pathways has a...
متن کاملEffects of leptin and obesity on the upper airway function.
Obesity is associated with alterations in upper airway collapsibility during sleep. Obese, leptin-deficient mice demonstrate blunted ventilatory control, leading us to hypothesize that (1) obesity and leptin deficiency would predispose to worsening neuromechanical upper airway function and that (2) leptin replacement would acutely reverse neuromuscular defects in the absence of weight loss. In ...
متن کاملEffect of age and weight on upper airway function in a mouse model.
Defects in pharyngeal mechanical and neuromuscular control are required for the development of obstructive sleep apnea. Obesity and age are known sleep apnea risk factors, leading us to hypothesize that specific defects in upper airway neuromechanical control are associated with weight and age in a mouse model. In anesthetized, spontaneously breathing young and old wild-type C57BL/6J mice, geni...
متن کاملEffect of Acute Intermittent CPAP Depressurization during Sleep in Obese Patients
BACKGROUND Obstructive Sleep Apnea (OSA) describes intermittent collapse of the airway during sleep, for which continuous positive airway pressure (CPAP) is often prescribed for treatment. Prior studies suggest that discontinuation of CPAP leads to a gradual, rather than immediate return of baseline severity of OSA. The objective of this study was to determine the extent of OSA recurrence durin...
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تاریخ انتشار 2004